Below some of the best Twitter desktop clients.This collection is pretty good . clients for Twitter – all of them use the Adobe AIR platform and can therefore run on Mac and Windows. Take a look and feel free to comment on them.
TweetDeck is your personal browser for staying in touch with what’s happening now, connecting you with your contacts across Twitter, Facebook and more.
TweetDeck shows you everything you want to see at once, so you can stay organised and up to date.
Seesmic Desktop is a cross-platform desktop Twitter client developed in Adobe AIR.
twhirl is a social software desktop client, based on the Adobe AIR
Download and install the latest twhirl release
Send files to your friends, but just dragging any file on to Tweetr. Tweetr will automatically upload your file and when it is done will provide a short url to send to your friends
Open source software using a New BSD-style license
Consists of a series of canvases that constantly update to keep tweets current and up-to-date using notifications that appear immediately after a new tweet arrives. DestroyTwitter also features complete direct messaging functionality.
Sideline is an Adobe® AIR™ desktop application built with the Yahoo! User Interface Library (YUI). It allows users to create and group custom queries by topics of interest.